March 20 | Sunday | 11:10 a.m. CT | 
Barclays Center | Brooklyn, N.Y. | 2nd Round
#2 Villanova Wildcats
- Coach: Jay Wright (13th NCAA Appearance)
- Key Wins: Butler (2x), Marquette (2x), Providence (2x), Seton Hall (2x), Xavier
- Record vs. RPI Top 50: 8-4
- NCAA Record: 55-35 (36th appearance)
- Last Appearance: Second Round (2015)
- Championships: 1 (1985)
#7 Iowa Hawkeyes
22-10 (12-6, 3rd Big Ten)
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- Coach: Fran McCaffery (8th NCAA Appearance)
- Key Wins: Michigan State (2), Purdue (2), Wichita State
- Record vs. RPI Top 50: 5-7
- NCAA Record: 28-26 (25th appearance)
- Last Appearance: Round of 32 (2015)
- Best Finish: Final Four (1955, 1956, 1980)