| QB | Beathard, C.J. | San Francisco 49ers | 6-10 | vs. Seattle - LOST 23-26 | 25-37, 273 yards, TD; 3 rushes, 10 yards | 66-104, 787 yards, 6 TDs, 6 rushes, 28 yards |
| OL | Blythe, Austin | Los Angeles Rams | 10-6 | vs. Arizona - WON 18-7 | Offense produced 333 total yards | Team averages 377 total net yards of offense per game- 11th in NFL |
| OL | Boettger, Ike | Buffalo Bills | 13-3 | vs. Miami - WON 56-26 | Offense produced 455 total yards | Team averages 396.4 total net yards of offense per game- 2nd in NFL |
| OL | Bulaga, Bryan | Los Angeles Chargers | 7-9 | @ Kansas City - WON 38-21 | Offense produced 416 total yards | Team averages 382.1 total net yards of offense per game- 9th in NFL |
| DL | Clayborn, Adrian | Cleveland Browns | 11-5 | vs. Pittsburgh - WON 24-22 | 1 TOT, 2 Qb hits | 12 TOT, 6 solo, 3.5 sacks, 5 TFLs, 8 QB hits, PBU |
| OL | Daniels, James; IR | Chicago Bears | 8-8 | vs. Green Bay - LOST 16-35 | Did not play (injured reserve) | Team averages 331.4 total net yards of offense per game- 26th in NFL |
| DL | Daniels, Mike | Cincinnati Bengals | 4-11-1 | vs. Baltimore - LOST 3-38 | Did not play (COVID) | 15 TOT, 6 solo, TFL |
| DL | Davis, Carl; IR | New England Patriots | 7-9 | vs. New York Jets - WON 28-14 | Did not play (injured reserve) | 3 TOT, 3 solo, TFL |
| DL | Epenesa, AJ | Buffalo Bills | 13-3 | vs. Miami - WON 56-26 | 3 TOT, 3 solo, Qb hit | 15 TOT, 15 solo, 4 TFL, 1.5 sacks, 5 QB hits, PBU |
| TE | Fant, Noah | Denver Broncos | 5-11 | vs. Las Vegas - LOST 31-32 | 4 catches, 48 yards | 62 catches, 673 yards, 3 TDs |
| OL | Ferentz, James | New England Patriots | 7-9 | vs. New York Jets - WON 28-14 | Offense produced 404 total yards | Team averages 327.3 total net yards of offense per game- 27th in NFL |
| DB | Gervase, Jake | Los Angeles Rams | 10-6 | vs. Arizona - WON 18-7 | Did not record any stats | Has not yet recorded any stats |
| TE | Hesse, Parker; PS | Tennessee Titans | 11-5 | vs. Houston - WON 41-38 | Did not play (practice squad) | Has not yet recorded any stats |
| LB | Hitchens, Anthony | Kansas City Chiefs | 14-2 | vs. Los Angeles Chargers - LOST 21-38 | Did not record any stats | 78 TOT, 44 solo, 2.5 TFL, 1 PBU, 4 Qb hits |
| TE | Hockenson, TJ | Detroit Lions | 6-10 | vs. Minnesota - LOST 35-37 | 3 catches, 25 yards | 67 catches, 723 yards, 6 TDs |
| DB | Hooker, Amani | Tennessee Titans | 11-5 | vs. Houston - WON 41-38 | 3 TOT, 2 solo, PBU, INT | 51 TOT, 35 solo, 8 PBUs, 4 INTs, TFL |
| DB | Hyde, Micah | Buffalo Bills | 13-3 | vs. Miami - WON 56-26 | 1 TOT, 1 solo | 69 TOT, 47 solo, TFL, 4 PBU, INT |
| DB | Jackson, Josh | Green Bay Packers | 13-3 | @ Chicago - WON 35-16 | Did not record any stats | 26 TOT, 21 solo, 2 PBU, TFL, 1 pun return, 7 yards |
| LB | Jewell, Josey | Denver Broncos | 5-11 | vs. Las Vegas - LOST 31-32 | 9 TOT, 5 solo, PBU | 112 TOT, 67 solo, 2 sacks, 6.0 TFLs, 4 PBU, 4 Qb hits |
| DT | Johnson, Jaleel | Minnesota Vikings | 7-9 | @ Detroit - WON 37-35 | Did not record any stats | 44 TOT, 22 solo, 3.5 TFL, 1.5 sack, 2 QB hit |
| DB | King, Desmond | Tennessee Titans | 11-5 | vs. Houston - WON 41-38 | 3 TOT, 3 solo, TFL, sack, Qb hit | 54 TOT, 40 solo, 2 TFLs, 2 PBUs, 2 sacks, 2 QB hits, fumble recovery, TD; 6 punt returns, 17 yards |
| LB | Kirksey, Christian | Green Bay Packers | 13-3 | @ Chicago - WON 35-16 | 7 TOT, 4 solo, TFL, sack, Qb hit | 78 TOT, 46 solo, 3 TFL, 2 sacks, 4 PBU, INT, 2 Qb hits |
| TE | Kittle, George; IR | San Francisco 49ers | 6-10 | vs. Seattle - LOST 23-26 | 7 catches, 68 yards | 48 catches, 634 yards, 2 TDs, 1 rush, 9 yards |
| LS | Kreiter, Casey | New York Giants | 6-10 | vs. Dallas - WON 23-19 | 1/1 FG, 2/3 XP | 31/32 FG, 21/23 XP |
| DL | Lattimore, Cedrick; PS | Seattle Seahawks | 12-4 | @ San Francisco - WON 26-23 | Did not play (practice squad) | Has not yet recorded any stats |
| DB | Mabin, Greg | Jacksonville Jaguars | 1-15 | @ Indianapolis - LOST 14-28 | 3 TOT, 3 solo | 21 TOT, 20 solo, 3 PBUs |
| DL | Nelson, Anthony | Tampa Bay Buccaneers | 11-5 | vs. Atlanta - WON 44-27 | 2 TOT, 1 solo, Qb hit | 14 TOT, 8 solo, sack, 3 TFL, 6 QB hits, PBU |
| DL | Nelson, Matt | Detroit Lions | 6-10 | vs. Minnesota - LOST 35-37 | Offense produced 417 total yards | Team averages 350.2 total net yards of offense per game- 20th in NFL |
| LB | Niemann, Ben | Kansas City Chiefs | 14-2 | vs. Los Angeles Chargers - LOST 21-38 | Did not record any stats | 44 TOT, 29 solo, 3.5 TFL, sack, 3 Qb hits, Fumble Recovery |
| DB | Ojemudia, Michael | Denver Broncos | 5-11 | vs. Las Vegas - LOST 31-32 | 7 TOT, 5 solo | 62 TOT, 55 solo, 6 PBU, 1 TFL, FF |
| OL | Reiff, Riley | Minnesota Vikings | 7-9 | @ Detroit - WON 37-35 | Did not play (COVID) | Team averages 393.3 total net yards of offense per game- 4th in NFL |
| OL | Reynolds, Ross | New England Patriots | 7-9 | vs. New York Jets - WON 28-14 | Offense produced 404 total yards | Team averages 327.3 total net yards of offense per game- 27th in NFL |
| OL | Scherff, Brandon | Washington Football Team | 7-9 | @ Philadelphia - WON 20-14 | Offense produced 248 total yards | Team averages 317.3 total net yards of offense per game- 30th in NFL |
| QB | Stanley, Nate; PS | Minnesota Vikings | 7-9 | @ Detroit - WON 37-35 | Did not play (practice squad) | Has not yet recorded any stats |
| DB | Stone, Geno | Houston Texans | 4-12 | vs. Tennessee - LOST 38-41 | Did not record any stats | Has not yet recorded any stats |
| LB | Welch, Kristian | Baltimore Ravens | 11-5 | @ Cincinnati - WON 38-3 | 1 TOT, 1 solo | 5 TOT, 3 solo |
| OL | Wirfs, Tristan | Tampa Bay Buccaneers | 11-5 | vs. Atlanta - WON 44-27 | Offense produced 485 total yards | Team averages 384.1 total net yards of offense per game- 7th in NFL |
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